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Year 2025

  • Yu X, Huang C, Evers M, Liu J, Ting HJ, Zhang S, Chong SY, Tan MS, Wang S, Sayed N, Gao L, Muthiah MD, Soon GST, Wee A, Chow EKH, Soh NJH, Pastorin G, Yu VC, Liu B, Dan YY, Torta F, Schiffelers R, Storm G, Wang JW*. Targeted Inhibition of Hepatic De Novo Ceramide Synthesis Ameliorates MASH. Sci Adv. 2025 Sep 26;11(39):eadx2681. doi: 10.1126/sciadv.adx2681. Epub 2025 Sep 26. (Featured by NUS Press Release, NUS News, Technology Networks, Lianhe Zaobao 联合早报).
  • Huang C#, Chng WH#, Neupane YR#, Lai Y, Cui W, Yang M, Wolfram J, Chong SY, Yu X, Zhang S, Zharkova O, Storm G, Pastorin G*, Wang JW*. Adipose stem cell-derived nanovesicles for cardioprotection: production and identification of therapeutic components. J Control Release. 2025 Sep 10:385:113989. Epub 2025 Jun 27. doi: 10.1016/j.jconrel.2025.113989. (Inside Cover Story).
  • Pei P, Chen Y, Chen X, Zhang F*, Liu X*, Wang JW*. Optothermal-Stimulated Persistent Luminescence Imaging and Therapy (OSPLIT). Advanced Materials. 2025 May;37(21):e2500769. Epub on 2025 Mar 31. doi:10.1002/adma.202500769. (Featured in the Chinese Journal of Structural Chemistry)
  • Lin Y, Huang C, Hou X, Kah JCY*, Wang JW*. Polydopamine and Hyaluronic Acid-coated dual-responsive silica nanoparticles for targeted atherosclerosis imaging and therapy. Nanoscale Adv. 2025 Oct 01. Doi: 10.1039/D5NA00497G. 
  • Wang H, Wei G, Yin J, Yang M, Tong L*, Wang JW*. Clinical insights into extracellular vesicles for targeted myocardial drug delivery. Expert Opin Drug Deliv. 2025 Sep 5:1-17. Epub on 2025 Aug 29. (Invited review). dot: 10.1080/17425247.2025.2555488.
  • Ou YH, Chng WH, Muthuramalingam RPK, Raghunathan P, Khunkitchai N, Lee CK, Jun JH, Ng ZX, Xin PT, Goh WJ, Wang JW, Czarny B. Delivery of antisense oligonucleotides using the nano-Cell Vesicle Technology system (nCVTs) for targeted cancer therapy. Small. 2025 Dec 16:e09094. doi: 10.1002/smll.202509094. Online ahead of print.
  • Chong B, Jayabaskaran J, Jauhari SM, Chia J, le Roux CW, Mehta A, Dimitriadis GK, Chen Y, Toh SA, Manla Y, Al Mahmeed W, Chan SP, Goh R, Nagarajan S, Li H, Kong G, Chin YH, Wang JW, Chew J, Kontopantelis E, Muthiah M, Tan JWC, Hausenloy D, Figtree GA, Mamas MA, Richards AM, Nicholls SJ, Chan MY, Lip GYH, Roth G, Mensah GA, Sperling LS, Chew NWS. The Global Syndemic of Modifiable Cardiovascular Risk Factors Projected From 2025 to 2050. J Am Coll Cardiol. 2025 Jul 22; 86 (3) 165–177. doi:10.1016/j.jacc.2025.04.061.
  • Carrera-Bravo C, Zhou T, Chu T, Hang JW, Modh H, Huang C, Zhang S, Hao H, Cabada-García MJ, Malleret B, Wacker MG, Wang JW, Rénia L, Tan KSW. Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile. Front. Cell. Infect. Microbiol. 2025 May 26: doi: 10.3389/fcimb.2025.1553123.
  • Liu T, Chen MH, Zhang CY, Xie T, Zhang S, Hao H, Bai ZY, Xue YZ, Wang JW, Xiao Y, Wei H, Chen LG. Hypertension inhibition by Dubosiella newyorkensis via reducing pentosidine synthesis. npj Biofilms and Microbiomes. 2025 Feb 22;11(1):34. Doi: 10.1038/s41522-025-00645-6. 

Year 2024

  • Tong L#, Wang Q#, Zhang Y, Lai F, Xu J, Yin W, Zhang S, Wei G, Yin J, Yi H, Storm G, Wang Z*, Huang R*, Xu T*, Wang JW*. Myocardial delivery of miR30d with targeting peptide-functionalized milk-derived extracellular vesicles for hypertrophic heart failure therapy. Biomaterials. 2025 May;316:122976. Epub on 2024 Nov 29. Doi: 10.1016/j.biomaterials.2024.122976.
  • Lin Y#, Liu J#, Chong SY#, Ting HJ, Tang X, Yang L, Zhang S, Qi X, Pei P, Yi Z, Huang C, Hou X, Gao L, Torta F, Liu X, Liu B*, Kah JCY*, Wang JW*. Dual-Function Nanoscale Coordination Polymer Nanoparticles for Targeted Diagnosis and Therapeutic Delivery in Atherosclerosis. Small. 2024 Nov;20(47):e2401659. doi: 10.1002/smll.202401659. Epub 2024 Aug 26. (Featured in NUS Press Release; reported by The Straits Times (online) and The Straits Times (print), AZO Nano, PHYS ORG, EurekAlert!, BioMed 科技, Zaobao 联合早报)
  • Zhang S, Wang Q, Tan DEL, Sikka V, Ng CH, Xian Y, Li D, Muthiah MD, Chew NWS, Storm G, Tong L*, Wang JW*. Gut-Liver Axis: Potential Mechanisms of Action of Food-derived Extracellular Vesicles. Journal of Extracellular Vesicles. 2024 Jun;13(6):e12466. doi: 10.1002/jev2.12466.
  • Pei P, Du Y, WangJW*, Liu X*. Nanomaterial-Mediated Modulation of TRPV1 Ion Channels for Biomedical Applications. Advanced Materials Technologies. 2024 Dec 03. doi: 10.1002/admt.202401355.
  • Shan Y, Li B, Liu X, Liu J, Wu C, Li Z, Wang D, Ting H, Wang JW, Liu B. Cascaded fingerprint recognition for non-alcoholic steatohepatitis imaging. Materials Today. 2024 Dec 17. doi: 10.1016/j.mattod.2024.11.016. 
  • Liu Y, Gao D, He Y, Ma J, Chong SY, Qi X, Ting HJ, Luo Z, Yi Z, Tang J, Chang C, Wang JW, Sheng Z, Zheng H, Liu X. Single-point mutated lanmodulin as a high-performance MRI contrast agent for vascular and kidney imaging. Nat Commun. 2024 Nov 13;15(1):9834. doi: 10.1038/s41467-024-54167-4.
  • Nagpal S, Palaniappan T, Wang JW, Wacker MG. Revisiting nanomedicine design strategies for follow-on products: A model-informed approach to optimize performance. J Control Release. 2024 Dec;376:1251-1270. Epub 2024 Nov 12. doi: 10.1016/j.jconrel.2024.11.004.
  • Koh J, Mohamed A, Kong G, Wong E, Chen Y, Anand VV, Chong B, Chin YH, Wang JW, Khoo CM, Chan SP, Muthiah M, Dimitriadis GK, Chan MY, Loh PH, Chew NWS. Long-term all-cause mortality of metabolic-dysfunction associated steatotic liver disease based on body weight phenotypes following acute myocardial infarction: A retrospective cohort study. Diabetes Obes Metab. 2024 Nov 11. doi: 10.1111/dom.16062. Online ahead of print.
  • Q Hua, JW Wang, D Li. Enhancement of microbial safety and shelf life of salmon fillets by Lactiplantibacillus plantarum 299 V fermented in pomelo (Citrus maxima) peel extract. Food Packaging and Shelf Life. 2024 Sep 26:46, 101359. doi.org/10.1016/j.fpsl.2024.101359
  • Chong B, Jayabaskaran J, Jauhari SM, Chan SP, Goh R, Kueh MTW, Li H, Chin YH, Kong G, Anand VV, Wang JW, Muthiah M, Jain V, Mehta A, Lim SL, Foo R, Figtree GA, Nicholls SJ, Mamas MA, Januzzi JL, Chew NWS, Richards AM, Chan MY. Global burden of cardiovascular diseases: projections from 2025 to 2050. Eur J Prev Cardiol. 2024 Sep 13:zwae281. doi: 10.1093/eurjpc/zwae281. Online ahead of print.
  • Goh RSJ, Chong B, Jayabaskaran J, Jauhari SM, Chan SP, Kueh MTW, Shankar K, Li H, Chin YH, Kong G, Anand VV, Chan KA, Sukmawati I, Toh SA, Muthiah M, Wang JW, Tse G, Mehta A, Fong A, Baskaran L, Zhong L, Yap J, Yeo KK, Hausenloy DJ, Tan JWC, Chao TF, Li YH, Lim SL, Chan KH, Loh PH, Chai P, Yeo TC, Low AF, Lee CH, Foo R, Tan HC, Yip J, Rao S, Honda S, Yasuda S, Kajiya T, Goto S, Yan BP, Zhou X, Figtree GA, Mamas MA, Kim Y, Jeong YH, Kim MH, Park DW, Park SJ, Richards AM, Chan MY, Lip GYH, Chew NWS. The burden of cardiovascular disease in Asia from 2025 to 2050: a forecast analysis for East Asia, South Asia, South-East Asia, Central Asia, and high-income Asia Pacific regions. Lancet Reg Health West Pac. 2024 Jul 10;49:101138. doi: 10.1016/j.lanwpc.2024.101138.
  • Kong G, Cao G, Koh J, Chan SP, Zhang A, Wong E, Chong B, Jauhari SM, Wang JW, Mehta A, Figtree GA, Mamas MA, Ng G, Chan KH, Chai P, Low AF, Lee CH, Yeo TC, Yip J, Foo R, Tan HC, Huang DQ, Muthiah M, Chan MY, Loh PH, Chew NWS. The prognostic value of metabolic dysfunction-associated steatotic liver disease in acute myocardial infarction: A propensity score-matched analysis. Diabetes Obes Metab. 2024 May 23. doi: 10.1111/dom.15660. Online ahead of print.
  • Tan J, Tan YY, Ngian ZK, Chong SY, Rao VK, Wang JW, Zeng X, Ong CT. ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression. iScience. 2024 Feb 15;27(3):109231. doi: 10.1016/j.isci.2024.109231. eCollection 2024 Mar 15. 
  • Liu J, Liu X, Shan Y, Ting HJ, Yu X, Wang JW, Liu B. Targeted Platelet with Hydrogen Peroxide Responsive Behavior for Non-Alcoholic Steatohepatitis Detection. Biomaterials. 2024 Apr;306:122506. doi: 10.1016/j.biomaterials.2024.122506. Epub 2024 Feb 8.

Year 2023

  • Tong L#, Zhang S#, Liu Q, Huang C, Hao H, Tan MS, Yu X, Lou CKL, Huang R, Zhang Z, Liu T, Gong P, Ng CH, Muthiah M, Pastorin G, Wacker MG, Chen X, Storm G, Lee CN, Zhang L, Yi H*, Wang JW*. Milk-derived extracellular vesicles protect intestinal barrier integrity in gut-liver axis. Sci Adv. 2023 Apr 14. 9(15):eade5041. doi: 10.1126/sciadv.ade5041. Epub 2023 Apr 12. (Reported by CNA (Channel NewsAsia), NEWS AZI, EurekAlert, NUS Press Release, X-MOL, PHYS.ORG, MIRAGE NEWS, and telephone interview by CNA938 Health Matters)
  • Chong SY, Wang X, van Bloois L, Huang C, Sayed N, Zhang S, Yu X, Ting HJ, Lin YZ, Tan MS, Lou CKL, Lim NJY, Lim HY, Lim SY, Thiam CH, Looi WD, Zharkova O, Chew NWS, Ng CH, Bonney GK, Muthiah M, Chen X, Pastorin G, Richards AM, Angeli V, Storm G, Wang JW. Injectable liposomal docosahexaenoic acid alleviates atherosclerosis progression and enhances plaque stability. J Control Release. 2023 Jul 7;360:344-364. doi: 10.1016/j.jconrel.2023.06.035. Online ahead of print. (Featured in NUSMed Press Release; Reported by 新加坡联合早报（zaobao)，BioMed 科技）
  • Liu J#, Yu X#, Ting HJ, Wang X, Xu S, Wang Y, Zhang S, Wang JW*, Liu B*. Myeloperoxidase-Sensitive T1 and T2 Switchable MR Imaging for Diagnosis of Nonalcoholic Steatohepatitis. ACS Nano. 2023 Feb 28;17(4):3324-3333. doi: 10.1021/acsnano.2c06233. Epub 2023 Feb 11. (NUS Press Release; Highlighted by ACS材料X, and telephone interview by CNA938 Health Matters)
  • Shan Y#, Sayed N#, Chong KC, Ting HJ, Liu X, Li B, Liu J, Wu M, Wang JW*, Liu B*. Imaging Fibrosis Progression in NASH with an Allysine-Reactive AIE Probe. ACS Materials Lett. 2023 Oct 31; 5, 3171–3176. doi : https://doi.org/10.1021/acsmaterialslett.3c00881
  • Cheah IK, Tang RMY, Wang X, Sachaphibulkij K, Chong SY, Lim LHK, Wang JW*, Halliwell B*. Protection against Doxorubicin-Induced Cardiotoxicity by Ergothioneine. Antioxidants (Basel). 2023. 30 January 2023, 12(2), 320; https://doi.org/10.3390/antiox12020320.
  • Pham TT, Le AH, Dang CP, Chong SY, Do DV, Peng B, Jayasinghe MK, Ong HB, Hoang DV, Louise RA, Loh YH, Hou HW, Wang JW, Le MT. Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis. J Extracell Vesicles. 2023 Aug;12(8):e12354. doi: 10.1002/jev2.12354.
  • Hou B, Yi L, Hu D, Luo Z, Gao D, Li C, Xing B, Wang JW, Lee CN, Zhang R, Sheng Z, Zhou B, Liu X. A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy. Nat Biomed Eng. 2023 Apr 13. doi: 10.1038/s41551-023-01024-2. Online ahead of print. (Reported by EurekAlert!, NUS Press Release, X-MOL, and news outlets ElectronicsWeekly, News8Plus, Bioengineer)
  • Chew NWS, Ng CH, Tan DJH, Kong G, Lin C, Chin YH, Lim WH, Huang DQ, Quek J, Fu CE, Xiao J, Syn N, Foo R, Khoo CM, Wang JW, Dimitriadis GK, Young DY, Siddiqui MS, Lam CSP, Wang Y, Figtree GA, Chan MY, Cummings DE, Noureddin M, Wong VW, Ma RCW, Mantzoros CS, Sanyal A, Muthiah MD. The global burden of metabolic disease: Data from 2000 to 2019. Cell Metab. 2023 Mar 7;35(3):414-428.e3. doi: 10.1016/j.cmet.2023.02.003. (Featured in Nature News)
  • Tan DJH, Ng CH, Muthiah M, Yong JN, Chee D, Teng M, Wong ZY, Zeng RW, Chin YH, Wang JW, Danpanichkul P, Rajaram RB, DasGupta R, Suzuki H, Takahashi H, Tamaki N, Dan YY, Lui R, Duseja A, Siddiqui MS, Yeoh KG, Sanyal A, Wijarnpreecha K, Loomba R, Mantzoros CS, Huang DQ. Rising global burden of cancer attributable to high BMI from 2010 to 2019. Metabolism. 2023 Nov 27:155744. doi: 10.1016/j.metabol.2023.155744. Online ahead of print.
  • Chan KE, Ong EYH, Chung CH, Ong CEY, Koh B, Tan DJH, Lim WH, Yong JN, Xiao J, Wong ZY, Syn N, Kaewdech A, Teng M, Wang JW, Chew N, Young DY, Kow A, Siddiqui MS, Huang DQ, Tamaki N, Wong VW, Mantzoros CS, Sanyal A, Noureddin M, Ng CH, Muthiah M. Longitudinal Outcomes Associated with Metabolic Dysfunction-Associated Steatotic Liver Disease. A Meta Analysis of 129 Studies. Clin Gastroenterol Hepatol. 2023 Sep 27:S1542-3565(23)00754-1. doi: 10.1016/j.cgh.2023.09.018. Online ahead of print.
  • Xia X, Li G, Dong Q, Wang JW, Kim JE. Endothelial Progenitor Cells as an Emerging Cardiovascular Risk Factor in the Field of Food and Nutrition Research: Advances and Challenges. Crit Rev Food Sci Nutr. 2023 Aug 21:1-18. doi: 10.1080/10408398.2023.2248506. Online ahead of print.
  • Chong B, Jayabaskaran J, Kong G, Chan YH, Chin YH, Goh R, Kannan S, Ng CH, Loong S, Tze MWK, Lin C, Anand VV, Lee ECZ, Chew J, Tan DJH, Chan KE, Wang JW, Muthiah MD, Mehta A, Dimitriadis GK, Hausenloy DJ, Foo R, Lip G, Chan MY, Mamas MA, Roux CWl, Chew NWS. Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019. eClinicalMedicine. Feb 2023. DOI:10.1016/j.eclinm.2023.101850
  • Chong B, Kong G, Shankar K, Chew HSJ, Lin C, Goh R, Chin YH, Tan DJH, Chan KE, Lim WH, Syn N, Chan SP, Wang JW, Khoo CM, Dimitriadis GK, Wijarnpreecha K, Sanyal A, Noureddin M, Siddiqui MS, Foo R, Mehta A, Figtree GA, Hausenloy DJ, Chan MY, Ng CH, Muthiah M, Mamas MA, Chew NWS. The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000-2019. Metabolism. 2023 Jan 28;141:155402. doi: 10.1016/j.metabol.2023.155402. Online ahead of print.
  • Lai ARX, Warrier M, Ng EZX, Lin C, Chin YH, Kong G, Anand VV, Lee ECZ, Lai H, Ng HW, Goh RSJ, Chong B, Muthiah MD, Khoo CM, Wang JW, Tse G, Loh PH, Mehta A, Brown A, Dimitriadis GK, Chan MY, Chew NWS. Cardiovascular Outcomes in Acute Coronary Syndrome and Malnutrition: A Meta-Analysis of Nutritional Assessment Tools. JACC: Advances. 2023 Oct, 2 (8) 100635. https://doi.org/10.1016/j.jacadv.2023.100635
  • Tan CY, Chan PS, Tan H, Tan SW, Lee CJM, Wang JW, Ye S, Werner H, Loh YJ, Lee YL, Matthew Ackers-Johnson M, Foo RSY, Jiang J. Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity. J Transl Med. 2023 Oct 16; 21(1):690. doi: 10.1186/s12967-023-04542-4
  • Anand VV, Zhe ELC, Chin YH, Goh RSJ, Lin C, Kueh MTW, Chong B, Kong G, Tay PWL, Dalakoti M, Muthiah M, Dimitriadis GK, Wang JW, Mehta A, Foo R, Tse G, Figtree GA, Loh PH, Chan MY, Mamas MA, Chew NWS. Socioeconomic deprivation and prognostic outcomes in acute coronary syndrome: A meta-analysis using multidimensional socioeconomic status indices. Int J Cardiol. 2023 Jul 15;383:140-150. doi: 10.1016/j.ijcard.2023.04.042. Epub 2023 Apr 26.
  • Chng WH, Muthuramalingam RPK, Lou CKL, New S, Neupane YR, Lee CK, Benetti AA, Huang C, Thoniyot P, Toh WS, Wang JW, Pastorin G. Extracellular Vesicles and Their Mimetics: A Comparative Study of Their Pharmacological Activities and Immunogenicity Profiles. Pharmaceutics. 2023 Apr 20, 15(4), 1290; doi: 10.3390/pharmaceutics15041290.
  • Carrera-Bravo C, Zhou T, Hang JW, Modh H, Huang F, Malleret B, Wacker MG, Wang JW, Renia L, Tan KSW. Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile.bioRxiv. Jan 2023. doi: https://doi.org/10.1101/2023.01.11.523595
  • Muthiah M, Ng CH, Chan KE, Fu CE, Lim WH, Tan DJH, Nah B, Kong G, Xiao J, Yong JN, Tan B, Syn N, Wang JW, Sayed N, Tan E, Chew NWS, Dan YY, Siddiqui MS, Sanyal AJ, Noureddin M. Type 2 diabetes mellitus in metabolic-associated fatty liver disease vs. type 2 diabetes mellitus non-alcoholic fatty liver disease: a longitudinal cohort analysis. Annals of Hepatology. 2023 Jan-Feb;28(1):100762. doi: 10.1016/j.aohep.2022.100762. Epub 2022 Sep 29..

Year 2022

  • Lim XC, Huang C, Yatim SMJM, Chong SY, Tan SH, Yang X, Heldt CL, Pedersen J, Talanker M, Modh H, Wacker MG, Pastorin G, Chan SP, Richards AM, Charles CJ, Chan MY*, Wang JW*. Temporal Changes in Extracellular Vesicle Hemostatic Protein Composition Predict Favourable Left Ventricular Remodeling after Acute Myocardial Infarction. International Journal of Molecular Sciences. 2022 Dec 25;24(1):327. doi: 10.3390/ijms24010327.
  • Lim XC, Yatim SM, Chong SY, Wang X, Tan SH, Yang X, Chan SP, Richards AM, Charles CJ, Chan MY*, Wang JW*. Plasma Tissue Factor Coagulation Activity in Post-Acute Myocardial Infarction Patients. Front Endocrinol (Lausanne). 2022 Sep 23;13:1008329. doi: 10.3389/fendo.2022.1008329. eCollection 2022.
  • Tong L, Zhang S, Huang R, Yi H, Wang JW. Extracellular vesicles as a novel photosensitive drug delivery system for enhanced photodynamic therapy. Frontiers in Bioengineering and Biotechnology. 2022 Sep 27;10:1032318. doi: 10.3389/fbioe.2022.1032318. eCollection 2022.
  • Lau CYJ, Benne N, Lou B, Zharkova O, Ting HJ, Ter Braake D, van Kronenburg N, Fens MH, Broere F, Hennink WE, Wang JW*, Mastrobattista E*. Modulating albumin-mediated transport of peptide-drug conjugates for antigen-specific Treg induction. J Control Release. 2022 Aug;348:938-950. doi: 10.1016/j.jconrel.2022.06.025.
  • Yu XD, Wang JW*. Ceramide de novo synthesis in non-alcoholic fatty liver disease: Pathogenic mechanisms and therapeutic perspectives. Biochem Pharmacol. 2022 Aug;202:115157. doi: 10.1016/j.bcp.2022.115157. Epub 2022 Jun 28.
  • Zhang Z#, Dalan R#, Hu Z#, Wang JW#, Chew NW, Poh KK, Tan RS, Soong TW, Dai Y, Ye L, Chen X. Reactive Oxygen Species Scavenging Nanomedicine for The Treatment of Ischemic Heart Disease. Adv Mater. 2022 Sep;34(35):e2202169. doi: 10.1002/adma.202202169. Epub 2022 Jul 28.
  • Chin YH, Ng CH, Chew NWS, Kong G, Lim WH, Tan DJH, Chan Ke, Tang A, Huang DQ, Chan MY, Figtree G, Wang JW, Shabbir A, Khoo CM, Wong VW, Dan YY, Siddiqui MS, Noureddin M, Sanyal A, Cummings DE, Syn N, Muthiah MD. The placebo response rate and nocebo events in obesity pharmacological trials. A systematic review and meta-analysis. 2022, 54 (101685). eClinicalMedicine. 2022 Sep 29;54:101685. doi: 10.1016/j.eclinm.2022.101685. eCollection 2022 Dec.
  • Neupane YR, Handral HK, Alkaff SA, Chng WH, Venkatesan G, Huang C, Lee CK, Wang JW, Sriram G, Dienzo RA, Lu WF, Ali Y, Czarny B, Pastorin G. Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing. Acta Pharmaceutica Sinica B. 15 November 2022. https://doi.org/10.1016/j.apsb.2022.10.022
  • Leonardi SS, Koh EY, Deng L, Huang C, Tong L, Wang JW, Tan KSW. The synthesis of extracellular vesicles by the protistan parasite Blastocystis. Frontiers in Cellular and Infection Microbiology. 2022 Oct 27;12:1019789. doi: 10.3389/fcimb.2022.1019789. eCollection 2022.
  • Chan KE, Ng CH, Fu CE, Quek J, Kong G, Goh YJ, Zeng RW, Tseng M, Aggarwal M, Nah B, Chee D, Wong ZY, Zhang S, Wang JW, Chew NWS, Dan YY, Siddiqui MS, Noureddin M, Sanyal AJ, Muthiah M. The Spectrum and Impact of Metabolic Dysfunction in MAFLD. A Longitudinal Cohort Analysis of 32,683 Overweight and Obese Individuals. Clinical Gastroenterology and Hepatology. 2022 Oct 3;S1542-3565(22)00926-0. doi: 10.1016/j.cgh.2022.09.028. Online ahead of print.
  • Muthiah M, Ng CH, Chan KE, Fu CE, Lim WH, Tan DJH, Nah B, Kong G, Xiao J, Yong JN, Tan B, Syn N, Wang JW, Sayed N, Tan E, Chew NW, Dan YY, Siddiqui MS, Sanyal AJ, Noureddin M. Type 2 diabetes mellitus in metabolic-associated fatty liver disease vs. type 2 diabetes mellitus Non-alcoholic fatty liver disease: a longitudinal cohort analysis. Ann Hepatol. 2022 Sep 28:100762. doi: 10.1016/j.aohep.2022.100762. Online ahead of print.
  • Chin YH, Lim O, Lin C, Chan YY, Kong G, Ng CH, Chong B, Syn N, Chan KE, Muthiah MD, Siddiqui MS, Wang JW, Figtree G, Chan MY, Chew NWS. Meta-analysis of the Placebo and Nocebo effects associated with Placebo treatment in randomized trials of lipid-lowering therapies. European Heart Journal-Quality of Care and Clinical Outcomes. 2022 Sep 15;qcac060. doi: 10.1093/ehjqcco/qcac060. Online ahead of print.
  • Ng CH, Teng MLP, Chew N, Chan KE, Yong JN, Quek J, Tan D, Lim WH, Lee GSJ, Wong J, Kaewdech A, Huang D, Wang JW, Chan MY, Noureddin M, Siddiqui MS, Sanyal A, Muthiah M. Statins decrease overall mortality and cancer related mortality but are underutilized in NAFLD: a longitudinal analysis of 12,538 individuals. Expert Rev Gastroenterol Hepatol. 2022 Sep;16(9):895-901. doi: 10.1080/17474124.2022.2119128. Epub 2022 Sep 2.
  • Ou YH, Liang J, Chng WH, Muthuramalingam RPK, Ng ZX, Lee CK, Neupane YR, Yau JNN, Zhang S, Lou CKL, Huang C, Wang JW, Pastorin G. Investigations on Cellular Uptake Mechanisms and Immunogenicity Profile of Novel Bio-Hybrid Nanovesicles. Pharmaceutics. 2022 Aug 20;14(8):1738. doi: 10.3390/pharmaceutics14081738.
  • Ng CH, Wong ZY, Chew NWS, Chan KE, Xiao J, Sayed N, Lim WH, Tan DJH, Loke RW, Tay PWL, Yong JN, Kong G, Huang DQ, Wang JW, Chan M, Dalakoti M, Tamaki N, Noureddin M, Siddiqui MS, Sanyal AJ, Muthiah M. Hypertension is prevalent in non-alcoholic fatty liver disease and increases all-cause and cardiovascular mortality. Front Cardiovasc Med.  2022 Aug 8;9:942753. doi: 10.3389/fcvm.2022.942753. eCollection 2022.
  • Wong CJK, Tai YK, Yap JLY, Fong CHH, Loo LSW, Kukumberg M, Fröhlich J, Zhang S, Li JZ, Wang JW, Rufaihah AJ, Franco-Obregón A. Brief exposure to directionally-specific pulsed electromagnetic fields stimulates extracellular vesicle release and is antagonized by streptomycin: A potential regenerative medicine and food industry paradigm. Biomaterials. 2022 Jul 6;287:121658. doi: 10.1016/j.biomaterials.2022.121658.
  • Tang A, Ng CH‚ Phang PH, Chan KE, Chin YH, Fu CE, Zeng RW, Xiao J, Tan DJH, Quek J, Lim WH, Mak LY, Wang JW, Chew NWS, Syn N, Huang DQ, Siddiqui MS, Sanyal A, Muthiah M, Noureddin M. Comparative Burden of Metabolic Dysfunction in Lean NAFLD vs. Non-Lean NAFLD – A Systematic Review and Meta-Analysis. Clin Gastroenterol Hepatol. 2022 Jul 19;S1542-3565(22)00669-3. doi: 10.1016/j.cgh.2022.06.029. Online ahead of print.
  • Lee CK, Zhang S, Venkatesan G, Lim I, Chong SY, Wang JW, Goh WJ, Panczyk T, Tay YZ, Hu J, Ng WK, Wacker MG, Toh WS, Pastorin G. Enhanced skin penetration of berberine from proniosome gel attenuates pain and inflammation in a mouse model of osteoarthritis. Biomater. Sci., 2022 Mar 29;10(7):1752-1764. doi: 10.1039/d1bm01733k. Epub 2022 Feb 17.
  • Xia X, Toh DWK, Ng SL, Zharkova O, Poh KK, Foo RSY, Wang JW, Kim JE. Impact of following a healthy dietary pattern with co-consuming wolfberry on number and function of blood outgrowth endothelial cells from middle-aged and older adults. Food & Function. 2022 Jan 4;13(1):76-90. doi: 10.1039/d1fo02369a. Epub 2021 Nov 22

Year 2021

  • Chong SY, Zharkova O, Yatim SMJ, Wang X, Lim XC, Huang C, Tan CY, Jiang J, Ye L, Tan MS, Angeli V, Versteeg HH, Dewerchin M, Carmeliet P, Lam CSP, Chan MY, de Kleijn DPV, Wang JW. Tissue factor cytoplasmic domain exacerbates post-infarct left ventricular remodeling via orchestrating cardiac inflammation and angiogenesis. Theranostics. 2021 Sep 3; 11(19):9243-9261. doi:10.7150/thno.63354. Reported by X-MOL
  • de Castilla PEM, Tong L, Huang C, Marios Sofias AM, Pastorin G, Chen X, Storm G, Schiffelers RM, Wang JW. Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies. Adv Drug Deliv Rev. 2021 Aug;175:113801. doi: 10.1016/j.addr.2021.05.011. Epub 2021 May 18.
  • Tong L, Hao H, Zhang Z, Lv Y, Liang X, Liu Q, Liu T, Gong P, Zhang L, Cao F, Pastorin G, Lee CN, Chen X, Wang JW*, Yi H*. Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota. Theranostics. 2021 Jul 25; 11(17):8570-8586. doi:10.7150/thno.62046. Featured in Channel NewsAsia and Interviewed by CNA Insider.
  • Neupane YR, Huang C, Wang X, Chng WH, Venkatesan G, Zharkova O, Wacker MG, Czarny B, Storm G, Wang JW*, Pastorin G*. Lyophilization Preserves the Intrinsic Cardioprotective Activity of Bioinspired Cell-Derived Nanovesicles. Pharmaceutics. 2021 Jul 9;13(7):1052. doi: 10.3390/pharmaceutics13071052.
  • Kalidasan V, Yang X, Xiong Z, Li RR, Yao H, Godaba H, Obuobi S, Singh P, Guan X, Tian X, Kurt SA, Li Z, Mukherjee D, Rajarethinam R, Chong CS, Wang JW, Ee PLR, Loke W, Tee BCK, Ouyang J, Charles CJ, Ho JS. Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds. Nat Biomed Eng. 2021 Oct;5(10):1217-1227. doi: 10.1038/s41551-021-00802-0. Epub 2021 Oct 15.
  • Meng QF, Tian R, Long H, Wu X, Lai J, Zharkova O, Wang JW*, Chen X*, Rao L*. Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID-19 Cytokine Storm. Adv Mater. 2021 May;33(20):e2100012. doi: 10.1002/adma.202100012. Epub 2021 Apr 10.
  • Wang S, Li X, Chong SY, Wang X, Chen H, Chen C, Ng LG, Wang JW and Liu B. In Vivo Three-Photon Imaging of Lipids Using Ultrabright Fluorogens with Aggregation-Induced Emission. Adv Mater. 2021 Mar;33(11):e2007490.  doi: 10.1002/adma.202007490.  Epub 2021 Feb 11.
  • Ou YH, Liang J, Czarny B, Wacker MG, Yu V, Wang JW*, Pastorin G*. Extracellular Vesicle (EV) biohybrid systems for cancer therapy: recent advances and future perspectives. Semin Cancer Biol. 2021 Feb 17:S1044-579X(21)00029-8. doi:10.1016/j.semcancer.2021.02.006.
  • Kessler EL, Wang JW, Kok B, Brans MA, Nederlof A, van Stuijvenberg L, Huang C, Vink A, Arslan F, Efimov IR, Lam CSP, Vos MA, de Kleijn DPV, Fontes MSC, van Veen TAB. Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice. Int J Mol Sci. 2021 Oct 30;22(21):11823. doi: 10.3390/ijms222111823.
  • Loo SY, Syn NL, Koh AP, Teng JC, Deivasigamani A, Tan TZ, Thike AA, Vali S, Kapoor S, Wang X, Wang JW, Tan PH, Yip GW, Sethi G, Huang RY, Hui KM, Wang L, Goh BC, Kumar AP. Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers. Cell Death Discov. 2021 Sep 27;7(1):265. doi: 10.1038/s41420-021-00635-5.
  • Yi Z, Gao H, JI X, Yeo X, Chong SY, Mao Y, Luo B, Shen C, Han S, Wang JW, Jung S, Shi P, Ren H, Liu X. Mapping Drug-Induced Neuropathy through In-Situ Motor Protein Tracking and Machine Learning. J Am Chem Soc. 2021 Sep 15;143(36):14907-14915.  doi: 10.1021/jacs.1c07312.  Epub 2021 Sep 1.
  • Sofias AM, De Lorenzi F, Peña Q, Azadkhah Shalmani A, Vucur M, Wang JW, Kiessling F, Shi Y, Consolino L, Storm G, Lammers T. Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders. Adv Drug Deliv Rev. 2021 Aug;175:113831. doi: 10.1016/j.addr.2021.113831. Epub 2021 Jun 15.
  • Mast MP, Modh H, Champanhac C, Wang JW, Storm G, Krämer J, Mailänder V, Pastorin G, Wacker MG. Nanomedicine at the crossroads – a quick guide for ivivc. Adv Drug Deliv Rev. 2021 Jun 23:113829. doi: 10.1016/j.addr.2021.113829.
  • Toh DWK, Xia X, Sutanto CN, Low JHM, Poh KK, Wang JW, Foo RSY, Kim JE. Enhancing the cardiovascular protective effects of a healthy dietary pattern with wolfberry (Lycium barbarum): a randomized controlled trial. Am J Clin Nutr. 2021 May 8:nqab062. doi: 10.1093/ajcn/nqab062.
  • Kukumberg M, Phermthai T, Wichitwiengrat S, Wang X, Arjunan S, Chong SY, Fong CY, Wang JW, Rufaihah AJ, Mattar CNZ. Hypoxia-induced amniotic fluid stem cell secretome augments cardiomyocyte proliferation and enhances cardioprotective effects under hypoxic-ischemic conditions. Sci Rep. 2021 Jan 8;11(1):163. doi: 10.1038/s41598-020-80326-w.
  • Ou YH, Zou S, Goh WJ, Wang JW, Wacker M, Czarny B, Pastorin G. Cell-Derived Nanovesicles as Exosome-Mimetics for Drug Delivery Purposes: Uses and Recommendations. Methods Mol Biol. 2021;2211:147-170. doi: 10.1007/978-1-0716-0943-9_11. (Book Chapter)
  • Huang C, Neupane YR, Lim XC, Shekhani R, Czarny B, Wacker MG, Pastorin G, Wang JW. Extracellular vesicles in cardiovascular diseases. Adv Clin Chem. 2021;103:47-95. doi: 10.1016/bs.acc.2020.08.006. Epub 2020 Oct 1. (Invited Book Chapter)

Year 2020

  • Verbree-Willemsen L, Zhang YN, Ibrahim I, Ooi SBS, Wang JW, Mazlan MI, Kuan WS, Chan SP, Peelen LM, Grobbee DE, Richards AM, Lam CSP, de Kleijn DPV. Extracellular vesicle CystatinC and CD14 are associated with both renal dysfunction and heart failure. ESC Heart Fail. 2020 Oct;7(5):2240-2249. doi: 10.1002/ehf2.12699. Epub 2020 Jul 10.
  • Ou YH, Zou S, Goh WJ, Chong SY, Venkatesan G, Wacker MG, Storm G, Wang JW*, Czarny B*, Pastorin G*, Woon ECY*. Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells. Nanoscale. 2020 Sep 21;12(35):18022-18030. doi: 10.1039/d0nr03784b. Epub 2020 Aug 28..
  • Tai YK, Ng C, Purnamawati K, Yap JLY, Yin JN, Wong C, Patel BK, Soong PL, Pelczar P, Fröhlich J, Beyer C, Fong CHH, Ramanan S, Casarosa M, Cerrato CP, Foo ZL, Pannir Selvan RM, Grishina E, Degirmenci U, Toh SJ, Richards PJ, Mirsaidi A, Wuertz-Kozak K, Chong SY, Ferguson SJ, Aguzzi A, Monici M, Sun L, Drum CL, Wang JW, Franco-Obregón A. Magnetic fields modulate metabolism and gut microbiome in correlation with Pgc-1α expression: Follow-up to an in vitro magnetic mitohormetic study. FASEB J. 2020 Aug;34(8):11143-11167. doi: 10.1096/fj.201903005RR. Epub 2020 Jul 6.
  • Jablonka L, Ashtikar M, Fiona Gao G, Thurn M, Modh H, Wang JW, Preuß A, Scheglmann D, Albrecht V, Röder B, Wacker MG. Predicting human pharmacokinetics of liposomal temoporfin using a hybrid in silico model. Eur J Pharm Biopharm. 2020 Apr;149:121-134. doi: 10.1016/j.ejpb.2020.02.001. Epub 2020 Feb 6.

Year 2019

  • de Kleijn DPV, Chong SY, Wang X, Yatim SM, Fairhurst AM, Vernooij F, Zharkova O, Chan M, Foo RSY, Timmers L, Lam CSP, Wang JW*. Toll-like Receptor 7 Deficiency Promotes Survival and Reduces Adverse Left Ventricular Remodeling After Myocardial Infarction. Cardiovasc Res. 2019 Oct 1;115(12):1791-1803. doi: 10.1093/cvr/cvz057. Epub 2019 Mar 4. (Highlighted by Editorial)
  • Tan CY, Wong JX, Chan PS, Tan H, Liao D, Chen W, Tan LW, Ackers-Johnson M, Wakimoto H, Seidman JG, Seidman CE, Lunde IG, Zhu F, Hu Q, Bian JS, Wang JW, Foo RS, Jiang J. Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of Bmp7 and Ctgf. Circ Res. 2019 Oct 11;125(9):834-846. doi: 10.1161/CIRCRESAHA.119.314794. Epub 2019 Sep 9.
  • Chong SY, Lee CK, Huang C, Ou YH, Charles CJ, Richards AM, Neupane YR, Pavon MV, Zharkova O, Pastorin G, Wang JW*. Extracellular Vesicles in Cardiovascular Diseases: Alternative Biomarker Sources, Therapeutic Agents, and Drug Delivery Carriers. Int J Mol Sci. 2019 Jul 3;20(13):3272. doi: 10.3390/ijms20133272.
  • Yap L#, Wang JW#, Moreno-Moral A, Chong LY, Sun Y, Harmston N, Wang X, Chong SY, Öhman M, Wei H, Bunte R, Gosh S, Cook S, Hovatta O, de Kleijn DPV, Petretto E, Tryggvason K. In vivo generation of post-infarct human cardiac muscle by laminin-promoted cardiovascular progenitors. Cell Reports. 2019 Mar 19;26(12):3231-3245.e9. doi: 10.1016/j.celrep.2019.02.083. (#First author).

Year 2018

  • Verbree-Willemsen L, Zhang YN, Gijsberts CM, Schoneveld AH, Wang JW, Lam CSP, Vernooij F, Bots ML, Peelen LM, Grobbee DE, Raichlen JS, de Kleijn DPV; On behalf of the METEOR Study Group. LDL extracellular vesicle coagulation protein levels change after initiation of statin therapy. Findings from the METEOR trial. Int J Cardiol., 2018 Nov 15;271:247-253. doi: 10.1016/j.ijcard.2018.05.098. Epub 2018 May 26.
  • Hu Z, Li G, Wang JW, Chong SY, Yu D, Wang X, Soon JL, Liang MC, Wong YP, Huang N, Colecraft HM, Liao P, Soong TW. Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction. Circulation. 2018 Oct 2;138(14):1431-1445. doi: 10.1161/CIRCULATIONAHA.117.031231.
  • Goh WJ, Zou S, Lee CK, Ou YH, Wang JW, Czarny B, Pastorin G. EXOPLEXs: Chimeric Drug Delivery Platform from the Fusion of Cell-Derived Nanovesicles and Liposomes. Biomacromolecules. 2018 Jan 8;19(1):22-30. doi: 10.1021/acs.biomac.7b01176. Epub 2017 Dec 8

Year 2017

  • Wang JW*, Zhang YN, Sze SK, van de Weg SM, Vernooij F, Schoneveld AH, Versteeg HH, Timmers L, Lam CSP, de Kleijn DPV*. Lowering Low-Density Lipoprotein Particles in Plasma Using Dextran Sulphate Co-Precipitates Procoagulant Extracellular Vesicles. Int J Mol Sci. 2017 Dec 29;19(1):94. doi: 10.3390/ijms19010094. (*Correspondence author)
  • Goh WJ, Zou S, Ong WY, Torta F, Fernandez AA, Schiffelers RM, Storm G, Wang JW, Czarny BM, Pastorin G. Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative. Sci Rep. 2017 Oct 30;7(1):14322. doi: 10.1038/s41598-017-14725-x
  • Wang JW, Fontes MSC, Wang X, Chong SY, Kessler EL, Zhang YN, de Haan JJ, Arslan F, de Jager SCA, Timmers L, van Veen TAB, Lam CSP, de Kleijn DPV. Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload. Sci Rep. 2017 Aug 23;7(1):9193. doi: 10.1038/s41598-017-09451-3.
  • Allijn IE, Czarny BM, Wang X, Chong SY, Weiler M, da Silva AE, Metselaar JM, Lam CS, Pastorin G, de Kleijn DP, Storm G, Wang JW*, Schiffelers RM*. Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction. J Control Release. 2017 Feb 10;247:127-133. doi: 10.1016/j.jconrel.2016.12.042. Epub 2017 Jan 5 (*Correspondence author)

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